Exciting Opportunity: Fully-Funded PhD Scholarship in mRNA Splicing at The Splice Lab, University of Southampton

The Splice Lab at the University of Southampton is thrilled to announce a fully-funded PhD scholarship position for the upcoming academic year. This opportunity is ideal for ambitious researchers eager to delve into the intricate world of mRNA splicing and its impact on protein synthesis. Under the guidance of Dr. Kif Liakath-Ali, this PhD position promises to offer a comprehensive exploration of the fundamental role of RNA splicing in cellular regulation.

Research Focus and Objectives

The focus of this PhD project is to investigate the regulatory mechanisms of RNA splicing and its implications for protein synthesis. RNA splicing is a critical process in gene expression, wherein precursor mRNA (pre-mRNA) transcripts are processed to form mature mRNA. This splicing process not only determines the diversity of proteins produced but also plays a pivotal role in cellular functions and disease mechanisms. The PhD candidate will engage in cutting-edge research utilizing a range of sophisticated techniques. Key methodologies include:

• CRISPR-Based Isoform Editing: This advanced tool will be employed to modify RNA splicing events and study their effects on protein isoforms.
• RNA Sequencing: High-throughput RNA sequencing will be used to analyze splicing patterns and identify novel splicing events.
• Spliceomics: The study of splice variants and their functional consequences will provide insights into the regulation of protein synthesis.
• Stem Cell-Based Functional Assays: These assays will help elucidate the role of alternative splicing in stem cell differentiation and function.

Through these approaches, the research aims to uncover the biological significance of alternative splicing in mammalian cells. The findings are expected to contribute significantly to the understanding of how alternative splicing regulates protein synthesis and impacts various physiological and pathological processes.

Why Apply?

This PhD position offers numerous benefits for prospective candidates:

1. Fully-Funded Scholarship: The position comes with full financial support covering tuition fees and a generous stipend, allowing the candidate to focus entirely on their research.
2. State-of-the-Art Facilities: The Splice Lab is equipped with cutting-edge technology and resources, providing an excellent environment for conducting high-impact research.
3. Expert Supervision: Dr. Kif Liakath-Ali is an esteemed researcher in the field of RNA biology, offering valuable mentorship and guidance throughout the PhD journey.
4. Career Development: The research experience gained through this position will be invaluable for future career opportunities in academia, industry, or other research-intensive roles.

Application Process

Interested candidates are encouraged to apply before the deadline on 30th August 2024. To learn more about the scholarship, including application procedures and eligibility criteria, please visit the following link: PhD Scholarship Application.